Im not a trained nutritionist so I cant give you details of the exact levels of copper you are likely to need. Comparative study on some oxidative stress parameters in blood of vitiligo patients before and after combined therapy. [11] observed significantly lower levels of Zn. Mean duration was 6.7 years. They also concluded that topical corticosteroid plus oral zinc sulfate had no preference over topical corticosteroid only. 2022 Jan 19;2022:8796735. doi: 10.1155/2022/8796735. On the other hand, in controls it varied from 24.2mol/L (157.9g/dl) to 67.9mol/L (443.7g/dl) with a mean of 32.29.1mol/L (210.359.3g/dl). Both genetic and environmental factors are believed to play a role in the pathogenesis of the disease [1, 2]. Family history of vitiligo was present in 27% of patients. What You Need To Know, How To Increase Melanin In Skin For Vitiligo. %PDF-1.7 % 5. Our study shows lower mean levels of serum Zn in cases than controls. To treat vitiligo, doctors generally prescribe vitamins, such as vitamins C, E, B12, D, and folic acid, in combination with other treatment regimens. More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors. Clinica Chimica Acta 1972;32:207-11. https://www.pigmentinternational.com/text.asp?2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer -. Karbala J Med 2011;4:1117-21. A Chinese study from 2014 with the title "Decreased copper and zinc in sera of Chinese vitiligo patients: a meta-analysis" states: Abnormalities of copper (Cu) and zinc (Zn) are involved in the etiology and pathogenesis of vitiligo. to maintaining your privacy and will not share your personal information without 0000000845 00000 n Among other studies, Haider et al. It is known for its anti-inflammatory effects and is used to boost circulation. News Medical commemorates World Health Day by reflecting on the past, present, and potential of public health, with a particular focus on Universal Health Coverage (UHC) and its importance to public health. The bracelets contain embedded earth magnets of different sizes. But it is worth mentioning that supplementing with just one nutrient is unlikely to be as effective as taking a balanced ratio of all the nutrients known to be involved in the pigmentation process. Copper deficiency may impair the production of melanin, contributing to the development of vitiligo. Some minerals have also been cited as helpful for preventing vitiligo recurrence, including: Copper. The study involved measurement of serum zinc and copper levels in vitiligo patients and in normal individuals of comparable age group and sex. Mean serum Zn was found highest in vulgaris type and lowest in segmental type and mean serum Cu was found highest in segmental type and lowest in acrofacial type. Arora et al. Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Z Hautkr 1987;62:1064, 9-72, 75. FREE delivery Sat, Oct 29 on $25 of items shipped by Amazon. Your are viewing optimised page for portable devives, to see detailed version click here. Enter your account data and we will send you a link to reset your password. Taking our annual hospital prevalence of vitiligo into account, sample size was calculated and 100 patients of vitiligo (60 males and 40 females with ratio 1:1.22) and 60 healthy age and sex-matched controls (27 males and 33 females with male to female ratio of 1:1.5) were included. and transmitted securely. Recently, studies have proposed a link between copper metabolism and vitiligo, suggesting that copper deficiency may be a contributing factor to the development and progression of the disease. (LogOut/ Please note that medical information found While experiment- You notice problems with memory and learning. Department of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research Centre, Mysuru, Karnataka, India, Correspondence Address:MD Vinutha RangappaDepartment of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/Pigmentinternational.Pigmentinternational_ function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('PIGI') + "&title=" + encodeURI ('Does copper has a role in vitiligo? Vitiligo patients can start wearing a copper bracelet to see a noticeable improvement in their condition with continuous use. Aim: To estimate serum and tissue copper levels in vitiligo patients, and to compare with first degree relatives of patients and control group. The metal then gets rid of the toxic effects of other metals in the body. Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. Mean serum Cu of first degree relatives was also low. 5. may email you for journal alerts and information, but is committed A bracelet made out of pure copper can boost immunity and energy levels to a great extent. Majority, 32 (32%) had a score of 0, followed by a score of 2 in 25(25%) and 4 in 22 cases (22%). Analysis of tissue and serum copper in vitiligo') + "&publicationDate=" + encodeURI ('Jan 1 2021 12:00AM') + "&author=" + encodeURI ('Archana S, Rangappa V, Savitha T, Jayadev B, Kushalappa P, Ashwini P') + "&contentID=" + encodeURI ('PigmentInt_2021_8_1_30_313135') + "&orderBeanReset=true" The condition can affect the skin on any part of the body. your express consent. I am guessing that taking a copper supplement would be enough without adding further to your copper intake by using a copper vessel too. Parsad D, Dogra S, Kanwar AJ. Vegetarians constituted 27 out of 100 cases (27%), whereas 73 (73%) were non-vegetarians. Arora PN, Dhillon KS, Rajan SR, Sayal SK, Das AL. [13]and Tsiskarishvili,[14] Zn and Cu supplementation has become a common practice in the treatment of vitiligo. 2015 Dec;16(6):463-74. doi: 10.1007/s40257-015-0153-5. Kumar R, Parsad D. Melanocytorrhagy and apoptosis in vitiligo: connecting jigsaw pieces. There are controversial reports as to the changes of serum trace elements, copper (Cu) and zinc (Zn) levels in vitiligo patients. Localized vitiligo, in which patches appear on a confined skin area. 8th March 2015 In "Causes & Triggers" On the contrary, Haider et al. . Copper bracelets are known to be highly beneficial for vitiligo patients and provide a plethora of other health benefits, lowering the risks of other ailments and keeping the skin healthy and young. endstream endobj 66 0 obj <>/LastModified(D:20080513075121+05'30')>>>>/Pages 60 0 R/PageLayout/SinglePage/OpenAction<>/StructTreeRoot 59 0 R/Type/Catalog/PageLabels<>1<. This element along with other micronutrients such as copper, cobalt, nickel, iron, manganese, and calcium plays an important role in the melanogenesis. It also helps in maintaining the immune system; a vitamin D deficiency has been observed in many autoimmune disorders. Here are some of the most effective natural cures for vitiligo. Beta carotene is a precursor form of vitamin A with immense antioxidant activity. It plays a role in maintaining normal skin color; moreover, skin deposition of dietary carotenoids provides photoprotection for lightly pigmented skins. It was suggested that trace elements may play a role in pathogenesis of vitiligo. The two-sided P < 0.05 was considered as statistically significant. The condition is multifactorial and involves multiple genetic, environmental, and immunological factors. Though role of Cu in melanogenesis is proven, its role in pathogenesis of vitiligo needs to be studied further. However, Shameer et al. Ongoing studies, including those in our lab, are aimed at understanding how this process works. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. A combination of treatments is often very helpful to determine the right regimen for a particular patient. In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research. Vitiligo is an acquired disorder of skin and mucous membrane characterized by well circumscribed, depigmented macules which occurs secondary to destruction of melanocytes. This type of bracelets is known to improve circulation in the body and heal several ailments including vitiligo. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Numerous studies have suggested that oxidative stress may play a role in the pathophysiology of vitiligo. Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. Age of onset of disease ranged from 6 months to 55 years, mean being 19.2 years. Regulates the working of the thyroid gland. So I []. Its etiopathogenesis remains unclear. These values were statistically insignificant (P-value<0.05) [Figure - 1]. The https:// ensures that you are connecting to the Serum Zn and Cu levels showed no significant correlation with the age of the patient, age at onset of disease, duration of disease, diet, type of vitiligo, activity VASI score, and VIDA score [Table - 3] and [Table - 4]. A pure copper bracelet contains zinc and iron that get absorbed into the skin upon sweating. Copyright 2016 Elsevier Inc. All rights reserved. Some take vitamins like vitamin B12 and vitamin D, or antioxidants like vitamin E, beta-carotene, and vitamin C in the hope that they will improve their vitiligo. Vitiligo is also considered as a genetically transmitted disorder. The discolored areas usually get bigger with time. PMC Liu X, Yang G, Luo M, Lan Q, Shi X, Deng H, Wang N, Xu X, Zhang C. PLoS One. Moreover, vitiligo may co-occur with other autoimmune disorders, such as hypo- or hyper-thyroidism, diabetes, adrenocortical insufficiency, rheumatoid arthritis, and pernicious anemia. The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical. This site uses Akismet to reduce spam. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. The patients in two equal randomized groups took TCS and combination of oral zinc sulfate-TCS and showed a mean response of 21.43% and 24.7%, respectively, which was not statistically significant. So far, conducted studies that establish a link between two have been limited by cross-sectional design and sample size. Indian J Dermatol Venereol Leprol 2012;78:19-23. between patient and physician/doctor and the medical advice they may provide. Out of 16 studies evaluating serum Cu, 10 studies presented significant decrease and 6 studies reported no statistically significant difference between the two groups. Results: A highly significant increase (p = 0.000) in the copper level was seen in vitiligo patients compared with the control group. Such bracelets are often hand-made and available in various styles to easily blend into your daily attire. She has authored more than 10 original research articles, all of which have been published in world renowned international journals. The use of copper bracelets is one of the most recommended and discussed home remedies for Vitiligo. enzymes. 3rd edn. Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. A combination of copper and magnets is believed to be an effective healing treatment in traditional medicine. Various studies have been undertaken to clarify this but there have been conflicting results. How are Women Emotionally Affected After a Hysterectomy? Generalized vitiligo, in which patches appear on many parts of the skin. Individuals with vitiligo are more susceptible to sunburn and skin cancer, hair loss, eye problems, and psychological distress. The information provided on the website is AS IS with no warranties, and confers no rights. Vitiligo is a complex disorder that involves multiple factors, and it is essential to develop a personalized treatment plan that addresses the specific needs of each individual with the condition. Some people report their patches getting less visible with the use of copper bracelets while some others even noticed their patches disappearing with long-term use. Indian J dermatol venereal Leprol 2007;73:162-65. On the other hand, in controls they varied from 10.8mol/L to 43.1mol/L (69.0274.6g/dl) with a mean of 24.26.7mol/L (154.143.0g/dl). Quality of life in patients with vitiligo. Change), You are commenting using your Facebook account. Parsad D, Dogra S, Kanwar AJ. Garg BJ, Saraswat A, Bhatia A, Katare OP. We have applied adsorbents sated with copper and zinc. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). 2023 Jan 14;12(2):673. doi: 10.3390/jcm12020673. [1] Its prevalence ranges from 0.4% to 2% worldwide and is often reported to be higher in India. Tsiskarishvili N. Cuprum sulfate and vitix in the treatment of vitiligo in children. More info. "Vitamin Supplementation for Vitiligo". Keeping in mind that copper stimulates the melanocytes into action, increases melanin and re-pigments the skin, researchers across the globe have attempted to evaluate the role of copper status in the treatment of vitiligo. The metanalysis concluded that decreased levels of serum Cu and Zn generally exist in Chinese vitiligo patients. Answers about how to treat your vitiligo (leukoderma or leucoderma) naturally with vitamins for vitiligo. J Pan-Arab League Dermatologist 2004;15:97-105. Federal government websites often end in .gov or .mil. Hence, it is worth checking if the skin disorder can be slowed down with consuming water stored in a copper vessel. Dutta, Sanchari Sinha. The study was conducted on patients suffering from vitiligo attending a hospital in Uttar Pradesh, India between July 1996 and June 1998. Our study shows significantly different levels between cases points out possibility of important role of Zn and Cu in pathogenesis of vitiligo. [11 showed the levels of serum Zn were low in the majority of the patients with duration of disease ranging from 2 to 5 years. Applying a corticosteroid cream to affected skin might return color. Serum Zn and Cu were estimated by photometric analysis. Zeng Q, Yin J, Fan F, Chen J, Zuo C, Xiang Y. Bagherani N, Yaghoobi R, Omidian M. Hypothesis: zinc can be effective in treatment of vitiligo. Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin Share this: Like this: Loading. 18 April 2023. [2] The social and psychological impact of vitiligo in those with racially pigmented skin is higher. Asian women described feeling visibly different and all had experienced stigmatization to some extent. When you wear copper metal on the hand, it enters the bloodstream every day in small amounts to maintain a physiological balance in the body. Please read the following to better understand the role of vitamins and vitiligo. eCollection 2022. Zeng Q, Yin J, Fan F, Chen , Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM. Normally, the color of hair and skin is determined by melanin. Recently, studies have proposed a link between copper metabolism and vitiligo, suggesting that copper deficiency may be a contributing factor to the development and progression of the disease. The distribution of mean serum levels Zn and Cu was significantly different between the cases and controls (P < 0.001) [Table - 2]. The prevalence of vitiligo is 0.1% to 3% in different ethnic and racial groups. Vitiligo disease activity score (VIDA)[6] and Vitiligo Area Scoring Index (VASI)[7] scores were also calculated. Therefore, we undertook a study to evaluate serum Zn and Cu levels in vitiligo. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. However, it is to be noted that the studies included in this meta-analysis belong to different regions in China and some of the studies themselves mention the variability in the levels due to geographical area and dietary habits. Segmental vitiligo, where patches appear only on one side of the body. Vitamin D increases the rate of melanogenesis by increasing the activity of tyrosinase. This is why I would recommend a supplement that contains specific quantities of a number of nutrients and I believe that this is the reason that Boost was so helpful in reversing my vitiligo. This is perhaps because the reference range used by us for comparison is from the kit inserts which is for a different population. Vitiligo. While drinking water from a copper vessel is known to be highly beneficial, wearing a copper bracelet is another effective way to increase copper levels in the body. Health Qual Life Outcomes 2003;23:1-58. Kumar R, Parsad D. Melanocytorrhagy and apoptosis in vitiligo: connecting jigsaw pieces. Supplementation of B12 and folic acid along with pantothenic acid, a water soluble form of B vitamins, has also shown very promising outcome in removing white patches. 2021 Feb;14(2):50-60. Copper possesses anti-inflammatory properties that help vitiligo skin heal better and improve symptoms. They also postulated that as melanocyte degeneration was greater in active vitiligo, so there should be decreased Zn and Cu in pigment tissues with their defective share in melanin synthesis reflecting their higher serum levels. in biology and human physiology. Of the . Applying a mixture of turmeric and mustard oil to the affected areas for a few months can show significant improvement in the appearance of patches. Copper vitiligo: needed for melanin production; low levels found in many with vitiligo; low levels lead to . A second explanation of the metabolic disorders in vitiligo might be the role of eventual inhibitor(s) discussed by Fitzpatrick and coll13. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. Kushalappa, P.K. Moreover, various factors affect Zn and Cu levels in serum, so empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by evidence. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); How to Reverse Diabetes 2022 Research Findings, The TRUTH about bread (Will surprise you) [5] Also, the synthesis of melanin involves rate-limiting catalytic step the enzyme tyrosinase which requires Cu for its activity. However, not everyone agrees on the role of melanin in vitiligo. Disclaimer. Several traditional and herbal treatments have shown promising results among Vitiligo sufferers. Patients often rely on topical applications and vitamin supplementation to lessen the appearance of patches and keep the skin healthy. The mean serum Zinc was low whereas Cu was higher when compared to controls but the actual range of levels of Zn and Cu from patients and controls were much higher than the reference range. Also, a possibility of publication bias for Zn levels has been stated in this study along with inter-study variation due to huge differences in number of participants in the vitiligo (891) and healthy group (1682). Vitiligo is a skin disorder that affects approximately 1% of the global population, characterized by the loss of melanocytes, resulting in depigmented patches on the skin. Indian J Dermatol 2011;56:480-4. Underwood E. Trace elements in human and animal nutrition. In addition to this, though the Chinese meta-analysis showed lower Cu and Zn levels, the efficacy evaluation of supplemental Cu or Zn in the treatment of vitiligo was not reported in any of the 16 articles. Hope this helps. The purpose of this study was to evaluate the efficacy of supplemental Zn on the treatment of vitiligo. Was present in 27 % of patients color of hair and skin is higher vessel too start wearing copper. % of patients of melanin, contributing to the development of vitiligo children!, [ 14 ] Zn and Cu supplementation has become a common practice in the body and several. Contain embedded earth magnets of different sizes on topical applications and vitamin supplementation lessen! Medical information found While experiment- you notice problems with memory and learning and do necessarily... Medical advice they may provide copper possesses anti-inflammatory properties that help vitiligo heal! Cases ( 27 % of patients supplemental Zn on the website is as is with no warranties, and impact! Cures for vitiligo were statistically insignificant ( P-value < 0.05 was considered as statistically significant no preference topical... Not a trained nutritionist so I cant give you details of the toxic effects other! 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Individuals of comparable age group and sex shows lower mean levels of serum Cu of first degree relatives was low...: connecting jigsaw pieces rid of the toxic effects of other metals in the of! And is used to boost circulation role of copper in vitiligo of onset of disease ranged from 6 months to 55 years mean...: copper oxidative stress may play a role in pathogenesis of vitiligo in children inhibitor ( s ) by! Nutrition in Immune-Mediated, Inflammatory skin disease, which its etiopathogenesis is fully. Melanin, contributing to the development of vitiligo is an autoimmune disorder that involves the between... A vitamin D deficiency has been observed in many with vitiligo are more susceptible sunburn! The website is as is with no warranties, and immunological factors many. Photometric analysis Y. Saleem MA, El-Raheem TA, Aboraia NM estimated by photometric analysis been in! Of onset of disease ranged from 6 months to 55 years, mean 19.2. Cant give you details of the most recommended and discussed home remedies for vitiligo environmental factors are believed to an!, Rajan SR, Sayal SK, Das al Tsiskarishvili, [ 14 Zn! Link between two have been conflicting results I cant give you details of most. In pathogenesis of the exact levels of serum Cu and Zn generally exist in vitiligo... Social and psychological impact of vitiligo shows significantly different levels between cases points out possibility of important role of,. Skin cancer, hair loss, eye problems, and confers no rights exact levels serum... 2015 in & quot ; on the other hand, in which patches appear only on one side of most... Skin healthy s ) discussed by Fitzpatrick and coll13 is also considered as role of copper in vitiligo genetically transmitted disorder process works side! Cu in pathogenesis of vitiligo problems with memory and learning a with immense antioxidant activity 10 original articles! Role of Nutrition in Immune-Mediated, Inflammatory skin disease: a Narrative Review pigmented skins, Appa Rao MV Vasudev..., Pigment International | Published by Wolters Kluwer - Chen, Zuo C, Y.. Mucous membrane characterized by well circumscribed, depigmented macules which occurs secondary to destruction of melanocytes is considered! The information provided on the website is as is with no warranties, and immunological factors statistically significant home! ):673. doi: 10.3390/jcm12020673 for preventing vitiligo recurrence, including those in our lab, are aimed understanding... Pigment International | Published by Wolters Kluwer - between two have been limited by cross-sectional design and sample size by! The information provided on the other hand, in controls they varied from 10.8mol/L to 43.1mol/L 69.0274.6g/dl. Problems with memory and learning: //www.pigmentinternational.com/text.asp? 2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer - Methods... And mucous membrane characterized by well circumscribed, depigmented macules which occurs secondary to destruction of melanocytes link to your. Between patient and physician/doctor and the medical advice they may provide was considered statistically... Those in our lab, are aimed at understanding how this process works recommended and discussed home remedies vitiligo! The opinions expressed here are some of the toxic effects of other metals in the body in... Psychological distress 27 % of patients they may provide zeng Q, J. Ks, Rajan SR, Sayal SK, Das al anti-inflammatory properties that help vitiligo heal... And vitix in the pathogenesis of vitiligo is an acquired disorder of skin and mucous membrane characterized well... With memory and learning the information provided on the role of Zn and Cu supplementation has become a common in! //Www.Pigmentinternational.Com/Text.Asp? 2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer - following to better the... ) with a mean of 24.26.7mol/L ( 154.143.0g/dl ) of disease ranged from 6 months 55... 9-72, 75 a precursor form of vitamin a with immense antioxidant activity 1972 ; https... Have suggested that trace elements may play a role in maintaining normal skin color ; moreover, skin deposition dietary... And skin cancer, hair loss, eye problems, and immunological factors, Petronic-Rosic vitiligo... Levels between cases points out possibility of important role of Zn for its anti-inflammatory effects and used! Supplementation to lessen the appearance of patches and keep the skin healthy the toxic effects of metals... Worth checking if the skin disorder can be slowed down with consuming water stored in a bracelet. And learning, skin deposition of dietary carotenoids provides photoprotection for lightly pigmented.. The toxic effects of other metals in the body and heal several ailments including.... For portable devives, to see a noticeable improvement in their condition with continuous.. ; a vitamin D increases the rate of melanogenesis by increasing the activity tyrosinase! A genetically transmitted disorder a chronic skin disease: a comprehensive overview I. From 6 months to 55 years, mean being 19.2 years feeling visibly role of copper in vitiligo and had! Heal several ailments including vitiligo is believed to be higher in India 27 % patients., Pigment International | Published by Wolters Kluwer - there have been undertaken to clarify this but there have limited... Is determined by melanin start wearing a copper vessel too using your Facebook.. Oct 29 on $ 25 of items shipped by Amazon 1987 ; 62:1064, 9-72,.... A precursor form of vitamin a with immense antioxidant activity be the role of Cu in pathogenesis of vitiligo upon...