The FDA considers this level to be "very rare". She has not had any of the reactions everyone seems to be describing but she had respiratory distress. I tried everything but she just didnt have an appetite for anything. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. However, the following side effects are seen in less than 1 dog in 10,000 . Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Then gave me pills of prednisone for him to take 1 pill twice a day . She has what is called knuckling. While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. Dr said either Simparica (best case scenario), GOLPP or brain tumor. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). All is good! Your veterinarian may recommend a heartworm test if you are using Simparica Trio. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." Seizures. Can blocking GABA receptors also cause inflammation of spine? Stopped meds and he has had 3 more seizures since. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. He protected our livestock from coyotes for many years and I took good care of him. She is healing and has no new rashes or sores. Two weeks after first simparica dose.parasites gone. In fact, the production company performed a safety study that included a total of 808 dogs with different issues. She never did that before! Any response from the company? Never ever again with this med for him. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. The door is open , its where he prefers to sleep on a doggie bed . Glad i held off on the free sample i was given! She falls when she runs and when going up and down stairs. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. Thank you all so much for this thread and giving me hope. He hasn't eaten since and grazes on grass like he is a goat. Some dogs improve, some don't, not a clear answer why. Simparica is pretty new in England and it seems they are trialling it. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. He has trouble raising his leg to urinate. We spend last night at the Emergency Vet, and all day today at her normal vet. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. He is a 89 lbs 5 y/o pitbull who has never had any issues before. After I picked her up she just went back down and died on the way back to animal emergency room. He had ONE dose that evening and completely lost his appetite within a couple days. Im still confused. I left a lot out but didnt want to make too lengthy post. I used to use revolution but they dont cover ticks as well. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Gave our Brit simparica in October and shortly thereafter he had a seizure. No more Simperica for my dog! She didn't make it to the next day and died overnight. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . She went 11 days with no seizures and then had another gran mal. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. It really helped us to put this diarrhea condition in perspective. Simparica TRIO also works for the control and treatment of adult hookworm and adult roundworms. I am SO angry with my vet and so mad at myself for not researching first. About 11 months ago our vet recommended Simparica Trio. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. He seems sometimes anxious and is sensitive to noise outside. 13 March he is also very lethargic and sitll not eating (even his favorite treats). This spring I gave her one dose, and the tremors soon were back and much worse. Humans are another matter. I wish I could get this out of her system now. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. You seem like an idiot. Im praying over him too . Is it possible that Simparica could cause neurological issues with my dog. The prescription-only chewable tablet is given once a month to dogs and puppies eight weeks and older. Hi, Im wondering whats going on with your dog now? I've had to syringe water in his mouth. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. We wont be using this medicine ever again! I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. Product Details: Simparica Trio Chewables for dogs. The vet does not feel it is due to Simparica but i think it could be. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. My 15 yr old doodle wasnt given bravecto because of reviews. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. This junk needs to be pulled from the market. Never any issues with bravecto so we'll return to that medication. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. Hopefully yours will be lucky and return to normal. I paid $120 for 6 months of poison. Did you ever get to the bottom of redness in eyes? I have a completely different dog. By the evening she lost the use of her hind legs. Side effects of Simparica Let us now look at possible side effects when administering Simparica. He scratched at them which made it worse. Wow. I would, still boil chicken, carrots, potatoes for his meals. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! Simparica Trio: A One-Stop-Solution For Parasites. And has been for about 3 weeks. Its Sunday night and still vomiting. Has anyone else experienced this? The results are fatal for fleas and ticks but safe for mammals such as your dog. Hearing 35-40 to leave systems. This medicine needs to be stopped. This doesn't not sound like it would have anything to do with the action of Simparico. It's now March 23, he still has falls but not like at first. After second pill, weve notice he has been a bit down for a couple days. Them I took him to a vet for check up and to my horror, he has fleas and a tick. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. Is Simparica only available with a prescription? Use a collar or topical if you need to. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. She sensed his anxiety and uneasiness as him having sight issues. Thank you for this information. I am more than upset, I am effing pissed, my poor little boy. I know it's still in her system because I am still finding dead ticks that I miss because they are the size of a sesame seed. Vet office said make sure to give with food. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. Did you do this yourself or let the vet? #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. I gave my dog simparica trio. I hope I have found the culprit to his digression. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! I wish I read these side effects before my vet recommended Simparica Trio for my 12 week old Bichon. I should have kept with my gut feeling about any of these oral meds. Since she is young, the vet started us with Keppra. By Tuesday evening symptoms came back worse. My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! I wanted to investigate a bit before dosing him. The exact same thing is happening to my dog now. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. Will not eat or drink. He has been very lethargic and usually super active, jumping and chasing balls. I have given him bottle water but I don't think it is making it into him any longer. Also what are you looking at giving your dog as a seizure medication?? This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). Just wondering? Good bless you all. Oral use. We are beyond sad and livid! I don't give him much treat eather. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. Topical only for me from now on. He is 5 months old. Simparica has been approved by the FDA to treat and prevent flea and tick infestations. It started working on him right away, Diarrhea. I hate pills for me so I struggle giving this to him. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. Youre an idiot then! Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. The most common side effects of Simparica in dogs are vomiting and diarrhea. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. So you can imagine my worry now. Photo: AdobeStock/Monkey Business The FDA is warning pet parents that flea and tick medications may result in neurological issues. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. Not known if there be permanent after-effects. Lost all appetite. So your dog got better? Hello! Simparica has not been evaluated in pregnant, breeding or lactating dogs. four times. Now her dog is very sick and she has to take the dog to the vet every day in the past week. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. I am so upset - I gave it to him last week and he had an accident in the house. Strictly natural with zero side effects from now on. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. In our case the damage was permanent. 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